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CADPS calcium dependent secretion activator [ Homo sapiens (human) ]

Gene ID: 8618, updated on 28-Oct-2024

Summary

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Official Symbol
CADPSprovided by HGNC
Official Full Name
calcium dependent secretion activatorprovided by HGNC
Primary source
HGNC:HGNC:1426
See related
Ensembl:ENSG00000163618 MIM:604667; AllianceGenome:HGNC:1426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAPS; CAPS1; CADPS1; UNC-31
Summary
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
Expression
Biased expression in brain (RPKM 14.7), adrenal (RPKM 5.4) and 9 other tissues See more
Orthologs
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Genomic context

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See CADPS in Genome Data Viewer
Location:
3p14.2
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (62398348..62875416, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (62441892..62919090, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (62384023..62861091, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62354716-62355621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62357949-62358508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62358509-62359066 Neighboring gene VISTA enhancer hs435 Neighboring gene uncharacterized LOC105377647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62362229-62362828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62362829-62363426 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:62400506-62401328 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:62401329-62402151 Neighboring gene VISTA enhancer hs1316 Neighboring gene FEZ family zinc finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62523426-62524136 Neighboring gene Sharpr-MPRA regulatory region 8400 Neighboring gene Sharpr-MPRA regulatory region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:62654458-62654958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:62654959-62655459 Neighboring gene RNA, 7SL, cytoplasmic 863, pseudogene Neighboring gene ribosomal protein L14 pseudogene 2 Neighboring gene RNA, U6 small nuclear 139, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr3:62935781-62936282 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62936534-62937156 Neighboring gene NANOG hESC enhancer GRCh37_chr3:62940724-62941231 Neighboring gene ribosomal protein S10 pseudogene 10 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:63001433-63002163 Neighboring gene MPRA-validated peak4679 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:63082201-63082700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:63082748-63083248 Neighboring gene keratin 8 pseudogene 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C. Nishizaki T, et al. J Biol Chem, 1992 Nov 25. PMID 1429734
  2. Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients. Hattori K, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2011 Aug 15. PMID 21601610
  3. Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration. Wu B, et al. Oncol Rep, 2019 Dec. PMID 31638236, Free PMC Article
  4. CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma. Weng S, et al. Dig Dis Sci, 2020 Apr. PMID 31562609
  5. A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. Walent JH, et al. Cell, 1992 Sep 4. PMID 1516133

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
    Title: CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
  2. CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.
    Title: CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.
  3. Study revealed that CAPS1 promoted normal colonic epithelial FHC cells migration by altering the protein expression profile of exosomes derived from colorectal cancer cells cells. GW4869, an exosome inhibitor, inhibited CAPS1-induced cell migration.
    Title: Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration.
  4. CAPS1 promotes colorectal cancer metastasis through PI3K/Akt/GSK3beta/Snail signal pathway-mediated epithelial mesenchymal transformation process
    Title: CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation.
  5. the preferential binding of CAPS1 to open syntaxin-1 can contribute to the stabilization of the open state of syntaxin-1 during its transition from "closed" state to the SNARE complex formation.
    Title: Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.
  6. Increased level of CADPS protein, human in Schizophrenic patients
    Title: Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.
  7. Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
    Title: Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
  8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog
The genetic architecture of economic and political preferences.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1121

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal dense core vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
calcium-dependent secretion activator 1
Names
CAPS-1
Ca++-dependent secretion activator
Ca2+ dependent secretion activator
Ca2+-dependent activator protein for secretion
Ca2+-regulated cytoskeletal protein
calcium-dependent activator protein for secretion 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047093.1 RefSeqGene

    Range
    4974..482042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003716.4 → NP_003707.2  calcium-dependent secretion activator 1 isoform 1

    See identical proteins and their annotated locations for NP_003707.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC012519, AC092039, AC104161
    Consensus CDS
    CCDS46858.1
    UniProtKB/Swiss-Prot
    A6NF60, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2, Q9ULU8
    Related
    ENSP00000373215.4, ENST00000383710.9
    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836 → 940
    DUF1041; Domain of Unknown Function (DUF1041)

  2. NM_183393.3 → NP_899630.1  calcium-dependent secretion activator 1 isoform 3

    See identical proteins and their annotated locations for NP_899630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is the shortest isoform and lacks multiple internal regions, compared to isoform 1.
    Source sequence(s)
    AC012519, AC092039, AC104161
    Consensus CDS
    CCDS2898.1
    UniProtKB/Swiss-Prot
    Q9ULU8
    Related
    ENSP00000350632.3, ENST00000357948.7
    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:819 → 910
    DUF1041; Domain of Unknown Function (DUF1041)

  3. NM_183394.3 → NP_899631.1  calcium-dependent secretion activator 1 isoform 2

    See identical proteins and their annotated locations for NP_899631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than, and contains internal differences, compared to isoform 1.
    Source sequence(s)
    AC012519, AC092039, AC104161
    Consensus CDS
    CCDS2899.1
    UniProtKB/Swiss-Prot
    Q9ULU8
    Related
    ENSP00000283269.9, ENST00000283269.13
    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836 → 950
    DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    62398348..62875416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534200.4 → XP_011532502.1  calcium-dependent secretion activator 1 isoform X45

    See identical proteins and their annotated locations for XP_011532502.1

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836 → 927
    DUF1041; Domain of Unknown Function (DUF1041)

  2. XM_011534199.3 → XP_011532501.1  calcium-dependent secretion activator 1 isoform X43

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:836 → 927
    DUF1041; Domain of Unknown Function (DUF1041)

  3. XM_017007378.2 → XP_016862867.1  calcium-dependent secretion activator 1 isoform X35

  4. XM_011534198.4 → XP_011532500.1  calcium-dependent secretion activator 1 isoform X42

    See identical proteins and their annotated locations for XP_011532500.1

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836 → 933
    DUF1041; Domain of Unknown Function (DUF1041)

  5. XM_017007377.3 → XP_016862866.1  calcium-dependent secretion activator 1 isoform X34

  6. XM_011534191.4 → XP_011532493.1  calcium-dependent secretion activator 1 isoform X24

    See identical proteins and their annotated locations for XP_011532493.1

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:836 → 950
    DUF1041; Domain of Unknown Function (DUF1041)

  7. XM_017007368.2 → XP_016862857.1  calcium-dependent secretion activator 1 isoform X23

  8. XM_047449109.1 → XP_047305065.1  calcium-dependent secretion activator 1 isoform X47

  9. XM_047449107.1 → XP_047305063.1  calcium-dependent secretion activator 1 isoform X38

  10. XM_047449103.1 → XP_047305059.1  calcium-dependent secretion activator 1 isoform X22

  11. XM_011534197.3 → XP_011532499.1  calcium-dependent secretion activator 1 isoform X36

    See identical proteins and their annotated locations for XP_011532499.1

    UniProtKB/TrEMBL
    F1T0E5
    Related
    ENSP00000484365.1, ENST00000612439.4
    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:889 → 980
    DUF1041; Domain of Unknown Function (DUF1041)

  12. XM_047449105.1 → XP_047305061.1  calcium-dependent secretion activator 1 isoform X32

  13. XM_006713378.4 → XP_006713441.2  calcium-dependent secretion activator 1 isoform X44

    See identical proteins and their annotated locations for XP_006713441.2

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840 → 931
    DUF1041; Domain of Unknown Function (DUF1041)

  14. XM_047449108.1 → XP_047305064.1  calcium-dependent secretion activator 1 isoform X41

  15. XM_011534203.3 → XP_011532505.1  calcium-dependent secretion activator 1 isoform X48

    See identical proteins and their annotated locations for XP_011532505.1

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840 → 934
    DUF1041; Domain of Unknown Function (DUF1041)

  16. XM_011534196.3 → XP_011532498.1  calcium-dependent secretion activator 1 isoform X30

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:840 → 934
    DUF1041; Domain of Unknown Function (DUF1041)

  17. XM_017007386.3 → XP_016862875.1  calcium-dependent secretion activator 1 isoform X40

  18. XM_017007374.3 → XP_016862863.1  calcium-dependent secretion activator 1 isoform X31

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840 → 937
    DUF1041; Domain of Unknown Function (DUF1041)

  19. XM_011534194.3 → XP_011532496.1  calcium-dependent secretion activator 1 isoform X27

    See identical proteins and their annotated locations for XP_011532496.1

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:840 → 944
    DUF1041; Domain of Unknown Function (DUF1041)

  20. XM_011534193.3 → XP_011532495.1  calcium-dependent secretion activator 1 isoform X26

    Conserved Domains (1) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

  21. XM_017007383.3 → XP_016862872.1  calcium-dependent secretion activator 1 isoform X39

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:840 → 954
    DUF1041; Domain of Unknown Function (DUF1041)

  22. XM_047449106.1 → XP_047305062.1  calcium-dependent secretion activator 1 isoform X37

  23. XM_047449102.1 → XP_047305058.1  calcium-dependent secretion activator 1 isoform X20

  24. XM_017007376.3 → XP_016862865.1  calcium-dependent secretion activator 1 isoform X33

  25. XM_011534195.3 → XP_011532497.1  calcium-dependent secretion activator 1 isoform X29

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 984
    DUF1041; Domain of Unknown Function (DUF1041)

  26. XM_011534183.3 → XP_011532485.1  calcium-dependent secretion activator 1 isoform X14

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 984
    DUF1041; Domain of Unknown Function (DUF1041)

  27. XM_047449099.1 → XP_047305055.1  calcium-dependent secretion activator 1 isoform X11

  28. XM_017007371.3 → XP_016862860.1  calcium-dependent secretion activator 1 isoform X28

  29. XM_017007363.3 → XP_016862852.1  calcium-dependent secretion activator 1 isoform X13

  30. XM_011534182.3 → XP_011532484.1  calcium-dependent secretion activator 1 isoform X12

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 990
    DUF1041; Domain of Unknown Function (DUF1041)

  31. XM_011534180.3 → XP_011532482.1  calcium-dependent secretion activator 1 isoform X10

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 997
    DUF1041; Domain of Unknown Function (DUF1041)

  32. XM_011534192.3 → XP_011532494.1  calcium-dependent secretion activator 1 isoform X25

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 993
    DUF1041; Domain of Unknown Function (DUF1041)

  33. XM_047449098.1 → XP_047305054.1  calcium-dependent secretion activator 1 isoform X9

  34. XM_017007366.3 → XP_016862855.1  calcium-dependent secretion activator 1 isoform X21

    Conserved Domains (1) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

  35. XM_011534189.3 → XP_011532491.1  calcium-dependent secretion activator 1 isoform X18

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 1007
    DUF1041; Domain of Unknown Function (DUF1041)

  36. XM_047449097.1 → XP_047305053.1  calcium-dependent secretion activator 1 isoform X8

  37. XM_011534178.3 → XP_011532480.1  calcium-dependent secretion activator 1 isoform X7

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 1007
    DUF1041; Domain of Unknown Function (DUF1041)

  38. XM_047449094.1 → XP_047305050.1  calcium-dependent secretion activator 1 isoform X2

  39. XM_047449101.1 → XP_047305057.1  calcium-dependent secretion activator 1 isoform X19

  40. XM_047449100.1 → XP_047305056.1  calcium-dependent secretion activator 1 isoform X16

  41. XM_047449096.1 → XP_047305052.1  calcium-dependent secretion activator 1 isoform X5

  42. XM_047449095.1 → XP_047305051.1  calcium-dependent secretion activator 1 isoform X4

  43. XM_047449093.1 → XP_047305049.1  calcium-dependent secretion activator 1 isoform X1

  44. XM_017007364.3 → XP_016862853.1  calcium-dependent secretion activator 1 isoform X17

  45. XM_024453799.2 → XP_024309567.1  calcium-dependent secretion activator 1 isoform X15

    Conserved Domains (2) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:893 → 1013
    DUF1041; Domain of Unknown Function (DUF1041)

  46. XM_017007360.3 → XP_016862849.1  calcium-dependent secretion activator 1 isoform X6

  47. XM_011534177.3 → XP_011532479.1  calcium-dependent secretion activator 1 isoform X3

    Conserved Domains (4) summary
    smart00239
    Location:399 → 482
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 1013
    DUF1041; Domain of Unknown Function (DUF1041)

  48. XM_011534202.4 → XP_011532504.1  calcium-dependent secretion activator 1 isoform X46

    Conserved Domains (3) summary
    cd01234
    Location:515 → 634
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:523 → 622
    PH; PH domain
    pfam06292
    Location:893 → 918
    DUF1041; Domain of Unknown Function (DUF1041)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    62441892..62919090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348213.1 → XP_054204188.1  calcium-dependent secretion activator 1 isoform X45

  2. XM_054348211.1 → XP_054204186.1  calcium-dependent secretion activator 1 isoform X43

  3. XM_054348203.1 → XP_054204178.1  calcium-dependent secretion activator 1 isoform X35

  4. XM_054348210.1 → XP_054204185.1  calcium-dependent secretion activator 1 isoform X42

  5. XM_054348202.1 → XP_054204177.1  calcium-dependent secretion activator 1 isoform X34

  6. XM_054348192.1 → XP_054204167.1  calcium-dependent secretion activator 1 isoform X24

  7. XM_054348191.1 → XP_054204166.1  calcium-dependent secretion activator 1 isoform X23

  8. XM_054348214.1 → XP_054204189.1  calcium-dependent secretion activator 1 isoform X47

  9. XM_054348206.1 → XP_054204181.1  calcium-dependent secretion activator 1 isoform X38

  10. XM_054348190.1 → XP_054204165.1  calcium-dependent secretion activator 1 isoform X22

  11. XM_054348204.1 → XP_054204179.1  calcium-dependent secretion activator 1 isoform X36

    UniProtKB/TrEMBL
    F1T0E5

  12. XM_054348200.1 → XP_054204175.1  calcium-dependent secretion activator 1 isoform X32

  13. XM_054348170.1 → XP_054204145.1  calcium-dependent secretion activator 1 isoform X49

  14. XM_054348212.1 → XP_054204187.1  calcium-dependent secretion activator 1 isoform X44

  15. XM_054348209.1 → XP_054204184.1  calcium-dependent secretion activator 1 isoform X41

  16. XM_054348215.1 → XP_054204190.1  calcium-dependent secretion activator 1 isoform X48

  17. XM_054348198.1 → XP_054204173.1  calcium-dependent secretion activator 1 isoform X30

  18. XM_054348208.1 → XP_054204183.1  calcium-dependent secretion activator 1 isoform X40

  19. XM_054348199.1 → XP_054204174.1  calcium-dependent secretion activator 1 isoform X31

  20. XM_054348195.1 → XP_054204170.1  calcium-dependent secretion activator 1 isoform X27

  21. XM_054348194.1 → XP_054204169.1  calcium-dependent secretion activator 1 isoform X26

  22. XM_054348207.1 → XP_054204182.1  calcium-dependent secretion activator 1 isoform X39

  23. XM_054348205.1 → XP_054204180.1  calcium-dependent secretion activator 1 isoform X37

  24. XM_054348188.1 → XP_054204163.1  calcium-dependent secretion activator 1 isoform X20

  25. XM_054348201.1 → XP_054204176.1  calcium-dependent secretion activator 1 isoform X33

  26. XM_054348197.1 → XP_054204172.1  calcium-dependent secretion activator 1 isoform X29

  27. XM_054348182.1 → XP_054204157.1  calcium-dependent secretion activator 1 isoform X14

  28. XM_054348179.1 → XP_054204154.1  calcium-dependent secretion activator 1 isoform X11

  29. XM_054348196.1 → XP_054204171.1  calcium-dependent secretion activator 1 isoform X28

  30. XM_054348181.1 → XP_054204156.1  calcium-dependent secretion activator 1 isoform X13

  31. XM_054348180.1 → XP_054204155.1  calcium-dependent secretion activator 1 isoform X12

  32. XM_054348178.1 → XP_054204153.1  calcium-dependent secretion activator 1 isoform X10

  33. XM_054348193.1 → XP_054204168.1  calcium-dependent secretion activator 1 isoform X25

  34. XM_054348177.1 → XP_054204152.1  calcium-dependent secretion activator 1 isoform X9

  35. XM_054348189.1 → XP_054204164.1  calcium-dependent secretion activator 1 isoform X21

  36. XM_054348186.1 → XP_054204161.1  calcium-dependent secretion activator 1 isoform X18

  37. XM_054348176.1 → XP_054204151.1  calcium-dependent secretion activator 1 isoform X8

  38. XM_054348175.1 → XP_054204150.1  calcium-dependent secretion activator 1 isoform X7

  39. XM_054348169.1 → XP_054204144.1  calcium-dependent secretion activator 1 isoform X2

  40. XM_054348187.1 → XP_054204162.1  calcium-dependent secretion activator 1 isoform X19

  41. XM_054348184.1 → XP_054204159.1  calcium-dependent secretion activator 1 isoform X16

  42. XM_054348173.1 → XP_054204148.1  calcium-dependent secretion activator 1 isoform X5

  43. XM_054348172.1 → XP_054204147.1  calcium-dependent secretion activator 1 isoform X4

  44. XM_054348168.1 → XP_054204143.1  calcium-dependent secretion activator 1 isoform X1

  45. XM_054348185.1 → XP_054204160.1  calcium-dependent secretion activator 1 isoform X17

  46. XM_054348183.1 → XP_054204158.1  calcium-dependent secretion activator 1 isoform X15

  47. XM_054348174.1 → XP_054204149.1  calcium-dependent secretion activator 1 isoform X6

  48. XM_054348171.1 → XP_054204146.1  calcium-dependent secretion activator 1 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULU8.3 GenPept UniProtKB/Swiss-Prot:Q9ULU8

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